منابع مشابه
A review on the effects of urea in skin disorders
Alterations in barrier function are associated with a number of skin diseases, including xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor of the skin, plays an important role in the preservation of skin hydration and integrity. Several studies have investigated the effects of urea in the clinical setting. Here, we summarize the available clinical e...
متن کاملDesign and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases. Eight of these result from variants of connexin 26 (Cx26), a protein critically involved in cell-cell signaling in the inner ear and skin. Lack of non-toxic drugs with defined mechanisms of action poses a serious obstacle to t...
متن کاملPrevalence of skin disorders in athletes of 10 sport activities
Participation in sport activities has become increasingly popular, as a result, more patients are referred 10 dermatologists for disorders caused by sport activities. During most forms of exercise, the skin and it's appendages are under constant assault by traumatic and other environmental factors that can cause injury. Physical activity also predispose s the skin to infection and can exacer...
متن کاملtrans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation.
Dominant mutations of GJB2-encoding connexin-26 (Cx26) have pleiotropic effects, causing either hearing impairment (HI) alone or in association with palmoplantar keratoderma (PPK/HI). We examined a British family with the latter phenotype and identified a new dominant GJB2 mutation predicted to eliminate the amino acid residue E42 (DeltaE42) in Cx26. To dissect the pathomechanisms that result i...
متن کاملTerminology of Skin Disorders
Macroscopic appearances Macule (Fig. 7.1A) A flat, circumscribed lesion; an area of colour or textural change. Macules are seen in vitiligo (hypopigmentation), freckles (hyperpigmentation) and capillary haemangioma (red/purple). Papule (Fig. 7.1B) A solid, circumscribed, palpable elevation of skin less than 5 mm in diameter. They can appear in various forms: e.g. dome shaped (xanthomas), flat t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Communication & Adhesion
سال: 2001
ISSN: 1541-9061,1543-5180
DOI: 10.3109/15419060109080761